Ferretts IPS Liquid Iron Supplement – Iron Protein Succinylate

Ferretts IPS Oral Iron Solution – Iron Protein Succinylate

Advancement in the Treatment Of Iron Deficiency Anemia

Iron Deficiency: Global & US Prevalence

Conservative estimates indicate that at least 700 million individuals worldwide have overt iron deficiency, affecting 20-50% of population
Iron deficiency in the US is estimated to be:

Ages 1 – 2: 9% (males & females)

Ages 3 – 10: 6% (males & females)

Ages 11 – 14: 4-12% (males) & 6% (females)

Ages 15 – 44: 2% (males) & 3-14% (females)

Ages 45 – 74: 2% (males) & 6% (females)

Source: National Health and Nutrition Examination Study (NHANES)

Iron Deficiency: Prevalence in Athletes

Most athletes, especially females, have low – midrange hemoglobin values
Referred to as “sports anemia” and affects endurance athletes in particular, thus impairing sports performance
Incidences have been found to be 8-58% in male athletes and 40-80% in female athletes, which is far higher than in general population
Even marginal iron deficiency has been found to impair aerobic adaptation, and iron supplementation has been found to increase aerobic adaptation and exercise performance

Source: Brownlee, T., et al. Am J Clin Nutr 2002; 75:734-42

Anemia: When Body Iron is Inadequate

Iron is a mineral that is an essential constituent of blood and muscle and is required for the transport of oxygen
The primary role of iron relates to the ability of red blood cells to adequately carry oxygen for use throughout the entire body
When anemia is finally detected, an unbalanced condition has already been reached, and must be addressed

Symptoms of Iron Deficiency Range from Negligible To Severe Form

Iron deficiency develops insidiously and is often free of symptoms
Anemia symptoms include weakness, palpitations, lassitude, light-headedness, fatigue, and sometimes subtle behavioral changes
In children, iron deficiency can lead to behavior disorders, including lack of focus and poor memory

Several Factors Contribute To Iron Deficiency

Increased Iron Requirement:

Occurs during the growth spurts of infancy and adolescence
Occurs during pregnancy, where daily iron requirement increases about twofold
- A pregnant women’s recommended daily allowance doubles from 15 to 30 mg/day, and approx. 1,000 mg iron is needed to replace net losses and increased needs

Inadequate Iron Intake:

Diets low in animal proteins

Decreased Iron Absorption:

Partial or total gastrectomy
Chronic diarrhea or intestinal malabsorption

Blood Loss:

Menstrual blood loss accounts for the primary reason for iron deficiency among women
Gastrointestinal bleeding is the primary cause of iron deficiency among adult males

Volunteer blood donors

Iron Deficiency Anemia “High-Risk” Groups

People of low socio-economic status or limited education
Women with history of child-bearing difficulties, hemorrhaging, or multiple gestations
People with diets that are low in both meat and ascorbic acid
People who donate blood more than three times per year
Adolescents, especially male & female endurance athletes
Elderly
People who use aspirin regularly

ANEMIA Targeted Screening

To fully detect and evaluate iron deficiency, screening should not be limited to anemia markers such as hemoglobin, red cell count, hematocrit, and erythrocyte morphology
A specific marker such as serum ferritin is strictly linked to iron body storage and condition, and is the most precise indicator of actual iron status

Ferretts IPS fluid iron supplement Product Description

Ferretts IPS fluid iron supplement chemically corresponds to Iron Protein Succinylate (IPS) which is an iron compound bonded to a casein
Due to the succinylation process, the compound has a solubility profile strictly dependant on pH
Ferretts IPS has the advantage of precipitating in acid conditions and of being soluble at neutral and alkaline pH

Ferretts IPS in Gastric Environment
Insoluble at gastric pH

Ferretts IPS is insoluble at gastric pH, as it is gastro-protected through a casein protein layer (patented succinylation technology).Ferretts IPS, because of its unique gastro-protection, bypasses the gastric mucosa, where iron gastric intolerance most frequently occurs.

Ferretts IPS in Gastric Environment
Soluble at duodenal pH

Ferretts IPS, due to its gastro-protection is hydrolyzed by pancreatic enzymes, at duodenal pH levels only, and therefore the iron is rapidly absorbed into the bloodstream.Ferretts IPS is finally dissolved in the intestine where iron is rapidly absorbed.

Ferretts IPS fluid iron supplement: Superior Safety and Compliance

Superior gastric tolerability is ensured, through the absence of free iron remaining in the stomach
Iron Protein Succinylate’s improved gastric tolerance has been demonstrated in clinical settings
Clinical studies in about 3,500 patients showed absence of gastric side-effects in 93.7% of patients, while only 6.3% claimed one or more adverse events

	Baseline	Hours after administration
		1	2	3	4	5
Before meals	93±7	131±18	135±15	129±16	116±8	110±12
After meals	95±12	135±15	138±17	133±14	118±4	112±13

Ferretts IPS IPS Absorption Is Not Affected By Food Intake

Blood iron concentration (mean ± SD; n = 10) at different time points after administration of 80 mg of iron as protein succinylate complex, before or immediately after meals.

Ferretts IPS fluid iron supplement in Children
Results of IPS Treatment in Anemic Children, Mean Age 3-5 Years

Iron Protein Succinylate

Wide Patient Use
Over 3,000,000 patients have been treated.
Full clinical evaluation
Ca. 3,500 patients have been treated in clinical trials
Highest Safety Confirmed
93.7% of subjects reported no side effects

Ferretts IPS Fluid Iron Supplement Profile Summary

Ferretts IPS fluid iron supplement is safe and efficacious. Ferretts IPS contains iron wrapped in a casein protective layer, and does not dissolve in the gastric mucosa.
Ferretts IPS dissolves in the intestine as ferric iron, the active component is rapidly absorbed.
Ferretts IPS has a superior safety profile. Ferretts IPS allows long-lasting treatment, as is most often required for iron deficiency anemia.

Each 1 ml contains: . . . . . . . . 2.67 mg Elemental Iron
Each 5 ml contains: . . . . . . . 13.33 mg Elemental Iron
Each 7.5 ml contains: . . . . . . . 20 mg Elemental Iron
Each 10 ml contains: . . . . . . 26.67 mg Elemental Iron
Each 15 ml contains:. . . . . . . . 40 mg Elemental Iron

- From Iron Protein Succinylate

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